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cKO mice on HFD have improved insulin resistance. Male cKO mice and littermate controls were fed HFD for 16 weeks. Blood glucose levels after fasting for 6 h (A). ITT (B). n = 6–8 mice/group. GTT (C). n = 5 mice/group. Insulin-induced Akt phosphorylation determined by Western immunoblot analysis in pAT (D), skeletal muscle (E), and liver (F). *P < 0.05, **P < 0.01. Con, control.
