Table 1.
Echocardiography
| CTR | T2D + AAV-ctr | T2D + AAV-dnMCUb | Adjusted P values | ||
|---|---|---|---|---|---|
| T2D + AAV-ctr vs. CTR | T2D + AAV-ctr vs. T2D + AAV-dnMCUb | ||||
| BW (g) | 36 ± 3.6 | 55.17 ± 4.7 | 51.67 ± 2.6 | <0.0001*** | 0.2655 |
| HR M-mode (bpm) | 648.67 ± 50 | 596.17 ± 55 | 629.33 ± 20 | 0.1477 | 0.4155 |
| LVIDd (mm) | 4.05 ± 0.32 | 3.14 ± 0.24 | 3.25 ± 0.38 | 0.0008*** | 0.8104 |
| LVIDs (mm) | 2.59 ± 0.32 | 2.22 ± 0.08 | 2.00 ± 0.23 | 0.0425* | 0.2701 |
| %FS | 36.3 ± 3.4 | 29.03 ± 2.8 | 38.03 ± 4.7 | 0.014* | 0.0031** |
| IVSd (mm) | 0.75 ± 0.04 | 1.1 ± 0.07 | 0.99 ± 0.09 | <0.0001*** | 0.0569 |
| LVPWd (mm) | 0.71 ± 0.03 | 1.01 ± 0.11 | 0.94 ± 0.09 | <0.0001*** | 0.3847 |
| LVIDd/LVPWd | 5.75 ± 0.58 | 3.16 ± 0.65 | 3.48 ± 0.63 | <0.0001*** | 0.6519 |
| LVDd/BW | 0.114 ± 0.017 | 0.057 ± 0.006 | 0.06 ± 0.008 | <0.0001*** | 0.6411 |
| LVM(d) (mg) | 108.8 ± 13 | 120.43 ± 7.8 | 111.87 ± 17.7 | 0.3178 | 0.5135 |
| LVM/BW (mg/g) | 3.08 ± 0.61 | 2.19 ± 0.09 | 2.17 ± 0.35 | 0.0073** | 0.9957 |
Echocardiographic parameters were measured in six mice per group. Data are presented as mean ± SD. One-way ANOVA followed by Dunnett multiple-comparisons test was used for statistical analysis.
BW, body weight; %FS, percentage fractional shortening; HR, heart rate; IVSd, interventricular septal end diastole; LVDd, diastolic left ventricular dimension; LVIDd, left ventricular internal diameter in diastole; LVIDs, left ventricular internal diameter in systole; LVM(d), left ventricular mass in diastole; LVPWd, left ventricular posterior wall thickness in diastole.
*
Adjusted P < 0.05; **adjusted P < 0.01; ***adjusted P < 0.001.