Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic diagram represents the role of HO1 in regulating gluconeogenesis. HO1 overexpression produces excessive ferrous iron, which activates NF-κB in hepatocytes. As a consequence, Foxo1 is phosphorylated at Ser273, which activates the transcriptions of genes encoding for gluconeogenic enzymes. The figure was created with BioRender.com.
