Table 2.
No. of studies | Quality assessment | Relative effect (95% CI) | Absolute effect | Quality | ||||
---|---|---|---|---|---|---|---|---|
Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | ||||
All-cause mortality |
⊕⊕⊝⊝ LOW |
|||||||
7 | Seriousa | None | None | None | Suspectedb |
RR 0.85 (0.73–0.99) |
47 fewer per 1000 (from 3 fewer to 84 fewer) | |
A composite disease progression |
⊕⊕⊝⊝ LOW |
|||||||
4 | Seriousa | None | None | None | Suspectedb |
RR 0.85 (0.77–0.93) |
50 fewer per 1000 (from 23 fewer to 77 fewer) | |
Serious adverse events |
⊕⊕⊝⊝ LOW |
|||||||
4 | Seriousa | None | None | None | Suspectedb |
RR 1.13 (0.54–2.38) |
4 more per 1000 (from 16 fewer to 47 more) |
aSome included studies have high risk of bias according to risk of bias results
bDue to small number of included trials, publication bias cannot be excluded