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. 2021 Feb 21;6:83. doi: 10.1038/s41392-021-00521-7

Table 2.

Summary of findings for outcomes comparing corticosteroids vs. no corticosteroids

No. of studies Quality assessment Relative effect (95% CI) Absolute effect Quality
Risk of bias Inconsistency Indirectness Imprecision Publication bias
All-cause mortality

⊕⊕⊝⊝

LOW

 7 Seriousa None None None Suspectedb

RR 0.85

(0.73–0.99)

47 fewer per 1000 (from 3 fewer to 84 fewer)
A composite disease progression

⊕⊕⊝⊝

LOW

 4 Seriousa None None None Suspectedb

RR 0.85

(0.77–0.93)

50 fewer per 1000 (from 23 fewer to 77 fewer)
Serious adverse events

⊕⊕⊝⊝

LOW

 4 Seriousa None None None Suspectedb

RR 1.13

(0.54–2.38)

4 more per 1000 (from 16 fewer to 47 more)

aSome included studies have high risk of bias according to risk of bias results

bDue to small number of included trials, publication bias cannot be excluded