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. 2021 Feb 21;41(4):811–817. doi: 10.1007/s00296-021-04809-3

Table 1.

Clinical features, disease course and treatment approaches for FMF patients with COVID-19

Article Age/sex Type of study Diseases/severity Comorbidities Medical history Imaging findings Presenting Covid-19 symptoms Covid-19 treatment Management of disease
Kobak [15] 36/m Case report Patient had mild symptoms Obesity, hypertension Colchicine Not reported Headache, back pain, muscle and joint pain, fatigue, and loss of taste and smell Hydroxychloroquine, azithromycin, oseltamivir Colchicine continued, post-treatment PCR was negative
Bourguiba et al. [20] ?/1:1 Case series (27 FMF patients) 7 patients were hospitalized, imaged, and required oxygen therapy, 3 patients developed acute respiratory distress syndrome and were taken to the intensive care unit for mechanical ventilation and hemodialysis 2 patients died 4 patients: hypertension, 2 patients: cardiovascular disease, 1 patient: diabetes, 4 patients: chronic obstructive pulmonary disease, 2 patients: chronic kidney disease, 3 patients: AA amyloidosis Colchicine, interleukin-1 inhibitor, TNF alpha inhibitor 6 patients: Interstitial pneumonia in CT scan 17 patients: fever, 11 patients: cough, 11 patients: asthenia, 12 patients: shortness of breath, 9 patients: myalgia, 10 patients: anosmia, 7 patients: dysgeusia, 8 patients: headache, 2 patients: diarrhoea Not reported 26 patients: (15 patients: colchicine 1 mg/day, 5 patients: colchicine 1,5 mg/day, 5 patients: colchicine 2 mg/day, 1 patient: colchicine 2,5 mg/day), 4 patients: interleukin-1 inhibitor, 1 patient: TNF-α inhibitor
Haslak et al. [16] ?/3:3 Case series (6 FMF patients) 1 patient was hospitalized, 5 patients had mild symptoms Not reported 6 patients: colchicine 2 patients: ground glass opacity in thoracic CT scan 5 patients: Fever, 4 patients: dry cough, 3 patients: sore throat, 1 patient: dyspnea, 4 patients: diarrhea, 2 patients: myalgia 3 patients azithromycin, 4 patients oseltamivir, 5 patients HCQ 6 patients: colchicine
In this study Case series (3 PSA patients) Ambulatory: 2 patients, Hospitalized: 1 patient
55 F FMF Patient was hospitalized, monitored and given necessary oxygen therapy Hypertension, diabetes, asthma Colchicine Focal circular ground glass opacities in the lateral segment of the middle lobe in thoracic CT scan Dry cough, sore throat, dyspnea, diarrhea, loss of taste and smell Azitromisin, hydroxychloroquine, oseltamivir Colchicine
41 M FMF Patient had mild symptoms None Colchicine Chest X-ray not suggestive of SARS-CoV-2 infection Common joint and headache complaints Favipiravir, hydroxychloroquine Colchicine
73 F FMF Patient had mild symptoms Hypertension Colchicine Chest X-ray not suggestive of SARS-CoV-2 infection Dry cough, joint pain, headache, nausea, fever, loss of taste Favipravir Colchicine