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Effects of the guide length on KmAgo activity. (A) Effects of the 5′P-gDNA length on DNA cleavage activity. (B) Effects of the 5′P-gDNA length on RNA cleavage activity. (C) Effects of the 5′P-gRNA length on RNA cleavage activity. (D) Effects of the 5′P-gRNA length on DNA cleavage activity. Black triangle indicates the 30 nt 5′P-gRNA. All experiments were performed at the 4:2:1 KmAgo:guide:target molar ratio in reaction buffer containing Mn2+ ions for 15 min at 37°C.
