Table 4.

Information score of p21-5′ variants before and after horizontal swapping of half sites

Information scorea	ISc full site original datab	ISc full site after swappingb
LR mono	−11.40 ± 0.07	−11.480 ± 0.003
RL mono	−11.40 ± 0.05	−11.407 ± 0.003
RLminus mono	−11.60 ± 0.06	−11.170 ± 0.003
LR dinuc – term	0.96 ± 0.05	1.672 ± 0.004
RL dinuc – term	2.56 ± 0.04	1.878 ± 0.004
RLminus dinuc – term	2.41 ± 0.03	1.584 ± 0.004
LR dinuc – total	−12.40 ± 0.07	−13.15 ± 0.01
RL dinuc – total	−14.00 ± 0.04	−13.350 ± 0.004
RLminus dinuc – total	−14.00 ± 0.06	−12.75 ± 0.01

^aInformation score (ISc) represents the binding energy calculated from our 249 p53 REs training set for the indicated p21-5′ RE variants. 'mono' is ISc on the mononucleotide level; 'dinuc-term' is the term added to the mononucleotide ISc to yield the dinucleotide, total, ISc. See text for details.

^bValues of ISc presented here are not scaled to the best binder sequence as in Figure 7 and Supplementary Table S6. The ± are the standard error of the mean values, derived by the n – 1 Jackknife method (53). See text for details.