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Roles of lncRNAs in β-cell mass and function. Several lncRNAs, including PLUTO, MALAT1, and βlinc1 have been found to regulate β-cell function by modulating the expression of β-cell signature genes. LncRNAs as LEGLTBC and TUG1 protect β-cells from apoptosis in response to different stimuli. H19 and KCNQ1OT1 are involved in β-cell mass expansion during development, promoting β-cell proliferation.
