Table 3.
Summary and subgroup results for PSMs and clinicopathological features in PCa patients.
| Analysis specification | No. of studies | Study heterogeneity | Effects model | Pooled OR/SMD (95% CI) | P-Value | |
|---|---|---|---|---|---|---|
| I2 (%) | Pheterogeneity | |||||
| BMI | ||||||
| Overall | 3 | 83.2 | 0.003 | Random | 0.12 (–0.05,0.30) | 0.162 |
| p-PSA | ||||||
| Overall | 7 | 19.2 | 0.283 | Fixed | 0.37 (0.31,0.43) | <0.001 |
| SVI | ||||||
| Overall | 4 | 74.8 | 0.008 | Random | 4.19 (2.87,6.13) | <0.001 |
| Prostate volume | ||||||
| Overall | 3 | 76.3 | 0.015 | Random | –0.28 (–0.62,0.05) | 0.097 |
| Age | ||||||
| Overall | 9 | 57 | 0.017 | Random | 0.01 (–0.07,0.10) | 0.735 |
| Geographical region | ||||||
| Asian | 5 | 49.6 | 0.094 | Random | –0.03 (–0.17,0.12) | 0.724 |
| non-Asian | 4 | 36.4 | 0.193 | Fixed | 0.06 (–0.02,0.14) | 0.149 |
| Year of publication | ||||||
| ≥2014 | 5 | 75.6 | 0.003 | Random | –0.01 (–0.12,0.11) | 0.916 |
| <2014 | 4 | 0 | 0.543 | Fixed | 0.02 (–0.09,0.14) | 0.675 |
| No. of patients | ||||||
| ≥1,000 | 3 | 78.4 | 0.010 | Random | 0.05 (–0.07,0.16) | 0.442 |
| <1,000 | 6 | 34.0 | 0.182 | Fixed | –0.02 (–0.14,0.10) | 0.719 |
| Biopsy GS (<6/≥7) | ||||||
| Overall | 14 | 71.5 | <0.001 | Random | 1.53 (1.31,1.79) | <0.001 |
| Geographical region | ||||||
| Asian | 4 | 28.2 | 0.243 | Fixed | 1.19 (0.90,1.58) | 0.227 |
| non-Asian | 10 | 64.1 | 0.003 | Random | 1.65 (1.42,1.93) | <0.001 |
| Year of publication | ||||||
| ≥2014 | 9 | 64.8 | 0.004 | Random | 1.44 (1.17,1.76) | <0.001 |
| <2014 | 5 | 41.1 | 0.147 | Fixed | 1.75 (1.44,2.11) | <0.001 |
| No. of patients | ||||||
| ≥1,000 | 5 | 50.2 | 0.090 | Random | 1.84 (1.40,2.42) | <0.001 |
| <1,000 | 10 | 78.5 | <0.001 | Random | 1.39 (1.13,1.70) | 0.001 |
| Median follow-up | ||||||
| ≥70 months | 3 | 29.9 | 0.240 | Fixed | 1.58 (1.32,1.90) | <0.001 |
| <70 months | 6 | 68.1 | 0.008 | Random | 1.67 (1.13,2.46) | 0.010 |
| P-GS (<6/≥7) | ||||||
| Overall | 22 | 75.1 | <0.001 | Random | 2.49 (2.19,2.83) | <0.001 |
| Geographical region | ||||||
| Asian | 4 | 0 | 0.489 | Fixed | 2.47 (2.04,2.99) | <0.001 |
| non-Asian | 18 | 79.2 | <0.001 | Random | 2.48 (2.14,2.89) | <0.001 |
| Year of publication | ||||||
| ≥2014 | 9 | 74.3 | <0.001 | Random | 2.37 (1.90,2.96) | <0.001 |
| <2014 | 12 | 73.5 | <0.001 | Random | 2.48 (2.08,2.95) | <0.001 |
| No. of patients | ||||||
| ≥1,000 | 10 | 77.4 | <0.001 | Random | 2.49 (2.02,3.07) | <0.001 |
| <1,000 | 12 | 73.5 | <0.001 | Random | 2.48 (2.08,2.95) | <0.001 |
| Median follow-up | ||||||
| ≥70 months | 8 | 66.2 | 0.004 | Random | 2.04 (1.74,2.39) | <0.001 |
| <70 months | 9 | 76.6 | <0.001 | Random | 2.87 (2.27,3.62) | <0.001 |
| Stage (<T2/≥T3) | ||||||
| Overall | 23 | 91.4 | <0.001 | Random | 3.90 (3.18,4.79) | <0.001 |
| Geographical region | ||||||
| Asian | 6 | 0 | 0.592 | Fixed | 3.32 (2.75,4.00) | <0.001 |
| non-Asian | 17 | 93.9 | <0.001 | Random | 4.08 (3.19,5.22) | <0.001 |
| Year of publication | ||||||
| ≥2014 | 11 | 94.8 | <0.001 | Random | 3.28 (2.20,4.89) | <0.001 |
| <2014 | 12 | 82.5 | <0.001 | Random | 4.53 (3.64,5.64) | <0.001 |
| No. of patients | ||||||
| ≥1,000 | 10 | 94.3 | <0.001 | Random | 3.58 (2.74,4.69) | <0.001 |
| <1,000 | 13 | 87.9 | <0.001 | Random | 4.24 (2.88,6.25) | <0.001 |
| Median follow-up | ||||||
| ≥70 months | 7 | 75.8 | <0.001 | Random | 4.24 (3.42,5.26) | <0.001 |
| <70 months | 10 | 95.8 | <0.001 | Random | 3.58 (2.20,5.82) | <0.001 |
| Nerve sparing | ||||||
| Overall | 8 | 77.8 | <0.001 | Random | 0.90 (0.71,1.14) | 0.388 |
| Geographical region | ||||||
| Asian | 2 | 0 | 0.836 | Fixed | 1.04 (0.87,1.24) | 0.666 |
| non-Asian | 6 | 74.8 | 0.001 | Random | 0.86 (0.65,1.14) | 0.288 |
| Year of publication | ||||||
| ≥2014 | 5 | 86.1 | <0.001 | Random | 0.91 (0.67,1.24) | 0.564 |
| <2014 | 3 | 20.6 | 0.284 | Fixed | 0.87 (0.60,1.25) | 0.452 |
| No. of patients | ||||||
| ≥1,000 | 4 | 83.1 | 0.001 | Random | 0.74 (0.56,1.00) | 0.06 |
| <1,000 | 4 | 0 | 0.439 | Fixed | 1.23 (0.94,1.61) | 0.130 |
| Median follow-up | ||||||
| ≥70 months | 2 | 91.7 | 0.001 | Random | 1.05 (0.36,3.05) | 0.933 |
| <70 months | 4 | 22.0 | 0.279 | Fixed | 1.00 (0.81,1.23) | 0.990 |
| EPE | ||||||
| Overall | 5 | 82.3 | 0.001 | Random | 4.44 (3.25,6.09) | <0.001 |
| Year of publication | ||||||
| ≥2014 | 2 | 85.6 | 0.008 | Random | 4.16 (3.02,5.74) | <0.001 |
| <2014 | 3 | 87.2 | <0.001 | Random | 4.80 (1.97,11.68) | 0.001 |
| No. of patients | ||||||
| ≥1,000 | 2 | 85.6 | 0.008 | Random | 4.16 (3.02,5.74) | <0.001 |
| <1,000 | 3 | 87.2 | <0.001 | Random | 4.80 (1.97,11.68) | 0.001 |
| PLN | ||||||
| Overall | 7 | 70.8 | 0.002 | Random | 3.12 (2.28,4.27) | <0.001 |
| No. of patients | ||||||
| ≥1,000 | 4 | 56.4 | 0.076 | Random | 3.43 (2.66,4.54) | <0.001 |
| <1,000 | 3 | 72.0 | 0.028 | Random | 2.52 (1.06,5.99) | 0.037 |
| Median follow-up | ||||||
| ≥70 months | 3 | 82.8 | 0.003 | Random | 2.49 (1.07,5.79) | 0.033 |
| <70 months | 3 | 53.7 | 0.115 | Random | 3.18 (2.24,4.52) | <0.001 |