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. 2021 Feb 8;11:587561. doi: 10.3389/fendo.2020.587561

Table 2.

Association of miRNA polymorphisms with type 2 diabetes mellitus.

Genotype Crude models Adjusted models
OR(95%CI) P value OR(95%CI)a P value
miR-133a-1 rs8089787
CT vs CC 0.90(0.63, 1.27) 0.540 0.91(0.64, 1.29) 0.583
TT vs CC 1.00(0.32, 3.15) 0.995 1.05(0.33, 3.32) 0.929
CT+TT vs CC 0.90(0.64, 1.27) 0.558 0.91(0.65, 1.29) 0.603
miR-133a-2 rs13040413
CT vs CC 1.26(0.92, 1.75) 0.152 1.27(0.92, 1.76) 0.145
TT vs CC 2.19(1.10, 4.38) 0.026 2.18(1.09, 4.36) 0.028
CT+TT vs CC 1.38(1.01, 1.87) 0.041 1.38(1.02, 1.87) 0.040
let-7a-1 rs13293512
TC vs TT 1.35(0.97, 1.88) 0.074 1.34(0.97, 1.88) 0.080
CC vs TT 1.61(1.06, 2.44) 0.026 1.61(1.06, 2.44) 0.026
TC+CC vs TT 1.42(1.04, 1.93) 0.028 1.41(1.04, 1.93) 0.029
let-7f rs10877887
TC vs TT 1.22(0.90, 1.66) 0.197 1.21(0.89, 1.65) 0.219
CC vs TT 0.83(0.52, 1.31) 0.414 0.82(0.52, 1.30) 0.404
TC+CC vs TT 1.12(0.84, 1.49) 0.442 1.11(0.83, 1.48) 0.467
miR-27a rs895819
AG vs AA 1.26(0.93, 1.71) 0.138 1.26(0.93, 1.71) 0.134
GG vs AA 1.27(0.72, 2.23) 0.408 1.26(0.72, 2.22) 0.421
AG+GG vs AA 1.26(0.94, 1.68) 0.116 1.26(0.94, 1.68) 0.117

aORs and 95%CI and corresponding P values were calculated by logistic regression analysis adjusted by sex, age, smoking, drinking, hypertension, and dyslipidemia; OR, odds ratio; CI, confidence interval.