Table 3.
Stratified analysis of association between miRNA polymorphisms and type 2 diabetes mellitus.
| Genotype | Male | Female | ≥60 | <60 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR(95%CI)a | P value | OR(95%CI)a | P value | OR(95%CI)b | P value | OR(95%CI)b | P value | |||
| miR-133a-1 rs8089787 | ||||||||||
| CT | vs | CC | 0.76(0.45, 1.27) | 0.289 | 1.05(0.65, 1.70) | 0.850 | 1.31(0.70, 2.44) | 0.402 | 0.74(0.48, 1.14) | 0.165 |
| TT | vs | CC | 0.46(0.04, 5.07) | 0.522 | 1.36(0.36, 5.19) | 0.651 | 1.87(0.16, 21.35) | 0.616 | 0.86(0.23, 3.26) | 0.822 |
| CT+TT | vs | CC | 0.74(0.44, 1.23) | 0.248 | 1.07(0.67, 1.71) | 0.767 | 1.33(0.72, 2.45) | 0.367 | 0.74(0.49, 1.13) | 0.167 |
| miR-133a-2 rs13040413 | ||||||||||
| CT | vs | CC | 1.29(0.82, 2.02) | 0.274 | 1.21(0.76, 1.95) | 0.424 | 1.26(0.79, 2.010) | 0.336 | 1.20(0.76, 1.89) | 0.436 |
| TT | vs | CC | 2.27(0.76, 6.76) | 0.141 | 2.13(0.86, 5.27) | 0.103 | 5.42(1.52, 19.30) | 0.009 | 1.22(0.49, 3.05) | 0.672 |
| CT+TT | vs | CC | 1.38(0.90, 2.13) | 0.145 | 1.31(0.85, 2.04) | 0.226 | 1.50(0.96, 2.33) | 0.077 | 1.19(0.78, 1.83) | 0.425 |
| let-7a-1 rs13293512 | ||||||||||
| TC | vs | TT | 1.34(0.85, 2.11) | 0.213 | 1.35(0.84, 2.17) | 0.219 | 2.19(1.21, 3.97) | 0.010 | 1.08(0.72, 1.60) | 0.714 |
| CC | vs | TT | 1.87(1.03, 3.39) | 0.040 | 1.38(0.76, 2.50) | 0.287 | 2.40(1.37, 4.23) | 0.005 | 1.25(0.76, 2.05) | 0.375 |
| TC+CC | vs | TT | 1.47(0.95, 2.26) | 0.084 | 1.36(0.87, 2.13) | 0.179 | 3.20(1.42, 7.22) | 0.002 | 1.12(0.77, 1.64) | 0.545 |
| let-7f rs10877887 | ||||||||||
| TC | vs | TT | 1.17(0.77, 1.80) | 0.466 | 1.24(0.80, 1.93) | 0.336 | 1.44(0.82, 2.51) | 0.200 | 1.14(0.79, 1.65) | 0.486 |
| CC | vs | TT | 0.70(0.36, 1.36) | 0.290 | 1.01(0.52, 1.94) | 0.988 | 0.99(0.40, 2.46) | 0.986 | 0.82(0.48, 1.41) | 0.472 |
| TC+CC | vs | TT | 1.05(0.70, 1.57) | 0.808 | 1.18(0.78, 1.79) | 0.429 | 1.34(0.79, 2.27) | 0.282 | 1.05(0.75, 1.49) | 0.764 |
| miR-27a rs895819 | ||||||||||
| AG | vs | AA | 1.53(1.00, 2.34) | 0.049 | 1.02(0.66, 1.58) | 0.925 | 1.35(0.78, 2.34) | 0.289 | 1.23(0.85, 1.77) | 0.267 |
| GG | vs | AA | 1.50(0.69, 3.25) | 0.308 | 1.01(0.44, 2.33) | 0.977 | 4.92(1.01, 24.05) | 0.049 | 0.95(0.50, 1.80) | 0.874 |
| AG+GG | vs | AA | 1.59(1.07, 2.59) | 0.039 | 1.02(0.67, 1.54) | 0.942 | 1.53(0.90, 2.61) | 0.119 | 1.17(0.83, 1.66) | 0.366 |
aORs and 95%CI and corresponding P values were calculated by logistic regression analysis adjusted by age, smoking, drinking, hypertension, and dyslipidemia; bORs and 95%CI and corresponding P values were calculated by logistic regression analysis adjusted by sex, smoking, drinking, hypertension, and dyslipidemia; OR, odds ratio; CI, confidence interval.