Table 4.
SNP-environmental factors interaction effects on type 2 diabetes mellitus.
| Smoking (+) vs (-) | Drinking (+) vs (-) | Hypertension (+) vs (-) | Dyslipidemia (+) vs (-) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR(95%CI)a | P value | OR(95%CI)b | P value | OR(95%CI)c | P value | OR(95%CI)d | P value | |||
| miR-133a-1 rs8089787 | ||||||||||
| CT | vs | CC | 1.26(0.63, 2.56) | 0.514 | 0.78(0.36, 1.68) | 0.524 | 1.08(0.47, 2.49) | 0.857 | 0.73(0.26, 2.04) | 0.550 |
| TT | vs | CC | 4.77(0.32, 70.74) | 0.257 | 1.05(0.33, 3.30) | 0.935 | 1.87(0.12, 29.59) | 0.656 | 1.05(0.33, 3.30) | 0.935 |
| CT+TT | vs | CC | 1.36(0.68, 2.69) | 0.385 | 0.89(0.42, 1.89) | 0.756 | 1.13(0.50, 2.53) | 0.775 | 0.73(0.26, 2.01) | 0.538 |
| miR-133a-2 rs13040413 | ||||||||||
| CT | vs | CC | 1.02(0.54, 1.96) | 0.946 | 1.42(0.70, 2.90) | 0.333 | 1.82(0.86, 3.88) | 0.120 | 0.87(0.38, 1.96) | 0.730 |
| TT | vs | CC | 2.24(0.38, 13.14) | 0.371 | 1.87(0.95, 3.67) | 0.068 | 2.24(0.38, 13.14) | 0.371 | 1.08(0.21, 5.46) | 0.929 |
| CT+TT | vs | CC | 1.24(0.67, 2.29) | 0.491 | 10.26(2.08, 50.56) | 0.004 | 1.86(0.91, 3.82) | 0.089 | 0.92(0.43, 1.97) | 0.824 |
| let-7a-1 rs13293512 | ||||||||||
| TC | vs | TT | 2.04(1.00, 4.17) | 0.049 | 1.75(0.91, 3.39) | 0.096 | 1.06(0.51, 2.20) | 0.882 | 0.74(0.32, 1.75) | 0.498 |
| CC | vs | TT | 2.58(1.00, 6.68) | 0.051 | 1.93(1.03, 3.60) | 0.040 | 0.67(0.27, 1.66) | 0.382 | 1.00(0.33, 3.04) | 0.997 |
| TC+CC | vs | TT | 2.15(1.09, 4.23) | 0.027 | 2.56(1.09, 6.01) | 0.030 | 0.93(0.47, 1.84) | 0.828 | 0.80(0.35, 1.80) | 0.583 |
| let-7f rs10877887 | ||||||||||
| TC | vs | TT | 1.40(0.76, 2.58) | 0.286 | 1.50(0.76, 2.97) | 0.240 | 0.81(0.41, 1.61) | 0.551 | 0.55(0.25, 1.21) | 0.136 |
| CC | vs | TT | 1.74(0.69, 4.42) | 0.241 | 2.33(0.81, 6.69) | 0.116 | 1.11(0.38, 3.21) | 0.850 | 1.46(0.46, 4.66) | 0.520 |
| TC+CC | vs | TT | 1.46(0.82, 2.59) | 0.202 | 1.64(0.86, 3.11) | 0.134 | 0.88(0.46, 1.67) | 0.689 | 0.69(0.33, 1.43) | 0.318 |
| miR-27a rs895819 | ||||||||||
| AG | vs | AA | 1.11(0.61, 2.05) | 0.730 | 0.97(0.49, 1.91) | 0.926 | 1.18(0.59, 2.34) | 0.640 | 1.30(0.59, 2.84) | 0.518 |
| GG | vs | AA | 2.38(0.74, 7.67) | 0.147 | 0.77(0.21, 2.81) | 0.695 | 2.86(0.79, 10.43) | 0.111 | 0.79(0.20, 3.12) | 0.738 |
| AG+GG | vs | AA | 1.26(0.70, 2.24) | 0.442 | 0.93(0.49, 1.78) | 0.833 | 1.37(0.72, 2.63) | 0.340 | 1.18(0.57, 2.48) | 0.656 |
aORs and 95%CI and corresponding P values were calculated by logistic regression analysis adjusted by age, sex, drinking, hypertension, and dyslipidemia; b, ORs and 95%CI and corresponding P values were calculated by logistic regression analysis adjusted by age, sex, smoking, hypertension, and dyslipidemia; cORs and 95%CI and corresponding P values were calculated by logistic regression analysis adjusted by age, sex, smoking, drinking, and dyslipidemia; d ORs and 95%CI and corresponding P values were calculated by logistic regression analysis adjusted by age, sex, smoking, drinking, and hypertension; SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.