Table 1.
Summary of MIR211 target genes and their roles in various cancer types.
| TUMOR/CANCER TYPE | TARGET GENES | ASSOCIATED DYSREGULATED MECHANISMS | REFERENCES | |
|---|---|---|---|---|
| 1 | MELANOMA |
BRN2 (POU3F2)
PDK4 TGFBR2 NFAT5 RAB22A IL6 IGF2R BCL2 EDEM IGFBP5 AP1S2 SOX11 SERINC3 |
INVASION CELL GROWTH INVASION INVASION EMT INVASION CELL GROWTH APOPTOSIS PIGMENTATION |
(14, 25, 26, 32, 51–53) |
| 2 | MALIGANANT MELANOMA | PRAME | (54) | |
| 3 | MULTIPLE MYELOMA | CHOP | APOPTOSIS | (55) |
| 4 | THYROID CANCER | SOX11 | APOPTOSIS | (50) |
| 5 | EPITHELIAL OVARIAN CANCER | CYCLIN D1CDK1 | CELL CYCLE, APOPTOSIS | (45) |
| 7 | CERVICAL CANCER |
MUC4
SPARC ZEB1 |
INVASION & EMT EMT PROLIFERATION AND METASTSIS |
(16, 56, 57) |
| 10 | GASTRIC CANCER |
MMP-9
SOX4 |
EMT CANCER METASTASIS |
(58, 59) |
| 12 | BLADDER CANCER | SNAI1 | CANCER METASTASIS | (60) |
| 13 | OVARIAN CANCER | PHF-19 | PROLIFERATION, MIGRATION AND APOPTOSIS | (46) |
| 15 | GLIOBLASTIOMA |
MCM3AP-AS1
KLF5 |
ANGIOGENESIS ANGIOGENESIS |
(61) |
| 17 | HEPATOCELLULAR CARCINOMA |
SATB2
SPARC |
PROLIFERATION AND INVSION | (48, 62) |
| 19 | BREAST CANCER |
CDC25B
CCNB1 FOXM1 |
PROLIFERATION, MIGRATION AND INVASION | (63) |
| 22 | COLORECTAL CANCER | CDH5 | PROLIFERATION AND MIGRATION | (64) |
| 23 | ORAL SQUAMOUS CANCER | BIN1 | PROLIFERATION, MIGRATION AND INVASION | (65) |
| 24 | NON SMALL CELL LUNG CANCER | SRC1N1 | INVASION | (66) |
| 25 | HEAD AND NECK SQUAMOUS CELL CARCINOMA | TGFβRII | METASTASIS | (67) |