Fig. 1.

Types of cardiac tissue injury. Ischemia-reperfusion injury (IRI), permanent ligation injury (PLI), cryoinjury, resection, and gene ablation are the four main ways of studying cardiac injury and repair. IRI is used to simulate the pathological state of myocardial infarction (MI). The ligation is untied and blood reperfusion is performed after ligation of the mouse artery for 30 min Cryoinjury is caused by cauterization of ventricular tissue with a cryoprobe. Resection is used to surgically remove part of the cardiac tissues. The gene ablation method specifically expresses bacterial nitroreductase (NTR) or diphtheria toxin receptor (DTR) in cardiomyocytes (CMs) to result in CM death