Table 2.
Race-specific metabolic characteristics of obese youth with NGT, IGT and Type 2 diabetes.
| NGT (29B/44W) | IGT (14B/34W) | T2D (15B/16W) | ANOVA P | ||
|---|---|---|---|---|---|
| Hepatic IS (mg/kg/min per μU/mL)−1 | |||||
| AA | 16.8 ± 1.8 | 10.9 ± 1.3 | 11.5 ± 3.1 | 0.012 | |
| AW | 18.3 ± 1.4 | 12.1 ± 1.2 | 13.5 ± 2.8 | 0.002 | |
| Peripheral IS (mg/kg/min per uU/mL) | |||||
| AA | 2.1 ± 0.2 | 1.3 ± 0.2* | 1.2 ± 0.2 | 0.001 | |
| AW | 2.3 ± 0.2 | 1.9 ± 0.2 | 1.7 ± 0.3 | 0.024 | |
| 1st-phase insulin (uU/mL) | |||||
| AA | 379.9 ± 52* | 292.9 ± 36.7* | 187.6 ± 51.7* | 0.001 | |
| AW | 198.7 ± 18.4 | 204.3 ± 20.5 | 65.4 ± 9.6 | 0.0001 | |
| DI (mg/kg/min) | |||||
| AA | 683.9 ± 72.3* | 387.7 ± 78.2 | 138.8 ± 19.1* | 0.0001 | |
| AW | 403.7 ± 29.5 | 305.0 ± 24.1 | 92.0 ± 12.8 | 0.0001 | |
| Glucose-AUC (mg·dL−1·h−1) | |||||
| AA | 13618.2 ± 364.6* | 17930.1 ± 368.8 | 21092.5 ± 1337.8 | 0.0001 | |
| AW | 14860.8 ± 295.1 | 18418.3 ± 446.2 | 24402.2 ± 1190.8 | 0.0001 | |
AA: African American; AW: American White; IS: insulin sensitivity; DI: disposition index; AUC: area under the curve.
*
P<0.05 AA vs. AW in each glycemic group.