Figure 2.
Genomic analyses for mutations associated with differential response after chemoradiation. (A) Volcano plots of mutations associated with differential local-regional failure. Statistical significance (log10-transformed P values from log-rank test) was plotted against risk of local-regional failure (log2-fold change of Cox proportional hazard ratios). P values were corrected for multiple hypothesis testing. Mutations with significant P values after transformation (>-log10[0.05]) were labeled in red. (B) Volcano plots of any mutations associated with differential survival probability. (C) Volcano plots of deleterious mutations associated with differential local-regional failure. (D) Volcano plots of deleterious mutations associated with differential survival probability.