TABLE 2.

Incidence (percent) of drug‐related adverse events

Adverse event	Sorafenib + vitamik K		Sorafenib + vitamik K		P value
	Any grade	Grade 3	Any grade	Grade 3	Any grade	Grade 3
Overall incidence	91	59	91	64	0.50	0.55
Palmar‐plantar erythodysaesthesia	27	9	45	27	0.21	0.12
Aspantate aminotransferase increase	32	9	18	14	0.30	0.50
Rash/desquamation	32	5	14	9	0.15	0.50
Hypophosphatemia	32	9	5	5	0.02	0.50
Pancreatic amylase increase	23	14	23	9	1.00	0.50
Diarrhea	18	5	9	5	0.33	0.76
Fatigue	18	5	9	5	0.33	0.76
Hypertension	18	0	27	5	0.47	0.50
Hypothyroidism	14	0	0	0	0.12	NA
Dysphonia	9	0	14	0	0.50	NA
Alopecia	5	0	5	0	0.76	NA
Gastrointestinal hemorrhage	0	0	14	5	0.12	0.50