Table 4.
The Effect of Crude Urtica simensis and Solvent Fractions on Heart Weight to Body Weight Ratio
| Heart Weight to Body Weight Ratio | |||
|---|---|---|---|
| Experimental Groups | Heart Wt. | Body Wt. | Heart Wt./Body Wt. (×10−4) |
| Normal control (2% tween 80%) | 1.18±0.02 | 385.67±7.47 | 30.70±0.60 |
| Negative control CP(200mg/kg i.p) | 1.49±0.04 | 363.33±4.68 | 41.00±0.80a*** |
| Positive control (EN 10mg/kg/Po) | 1.08±0.04 | 343.67±7.37 | 31.30±0.90b*** |
| CE(100mg/kg)+CP(200mg/kg) | 1.16±0.02 | 358.17±9.38 | 32.70±1.10b*** |
| CE(200mg/kg)+CP(200mg/kg) | 1.09±0.03 | 341.33±7.64 | 31.80±0.50b*** |
| CE(400mg/kg)+CP(200mg/kg) | 1.12±0.02 | 355.83±6.24 | 31.50±0.40b*** |
| AF(200mg/kg)+ CP(200mg/kg) | 1.14±0.02 | 346.00±8.02 | 32.80±0.30b*** |
| AF(400mg/kg)+ CP(200mg/kg) | 1.14±0.07 | 351.00±8.58 | 32.30±1.80b*** |
| HF(200mg/kg)+ CP(200mg/kg) | 1.18±0.04 | 357.00±7.14 | 32.80±0.90b*** |
| HF(400mg/kg)+ CP(200mg/kg) | 1.21±0.05 | 370.00±5.11 | 32.50±1.20b*** |
Notes: Mean ±SEM (n= 6); analysis was performed using one-way ANOVA followed by Tukey post hoc test; aCompared with normal control; bCompared with negative control (CP); ***p<0.001.
Abbreviations: AF, aqueous fraction; CE, crude extract; CP, cyclophosphamide; EN, enalapril; HF, hexane fraction; Wt., weight.