Table 1.

Events in SCHISTOX simulation.

Event	Probability	Description
Birth of individuals	$Bin(N,b)$	The birth rate is set per 1000 individuals, and at each time point, the number of births is randomly selected from a binomial distribution with population size $\left(N\right)$ and birth rate ($b)$.
Death of an individual	Time of death is pre-determined for each individual.	Time of death is set at birth and is dependent on death rates per 1000 in each age bracket.
Egg production	$E~NegBin(\lambda W_p\exp \left(-z{W}_F\right),r)$	Number of eggs in individuals $\left(E\right)$ follow a negative binomial distribution with mean. It depends on the maximum fecundity $\left(\lambda \right)$, worm pairs $\left(W_P\right)$, number of female worms $\left(W_F\right)$ , exponential decay constant $\left(z\right)$, and aggregation parameter for egg production (r).
Worm maturity	$\frac{t_S{W}_S}{L_W\ast 365}$	$W_S$ is the worm stage,$\left(t_S\right)$ is the time step and $\left(L_W\right)$ is the average lifespan of the worms.
Miracidia production	$\frac{{\beta }_{age}E}{\text{max}\left({\beta }_{age}\right)}$	Eggs from each individual ($E)$ will be released into the environment relative to the maximum age dependent contact rate $\text{max}\left({\beta }_{age}\right)$.
Cercarial maturity	$\mu$	Number of days for miracidia to mature into cercarcia (life expectancy in the intermediate snail host used as a proxy).
Uptake of cercariae	$C~Poisson\left(\frac{t_S\beta {\beta }_{age}Py}{N}\right)$	Depends on overall contact rate $\left(\beta \right)$, age dependent contact rate $\left({\beta }_{age}\right)$ , individual predisposition $\left(P\right)$ and the available number cercariae in the environment $\left(y\right)$. It is density dependent as otherwise if the population grows, then the relative rate of uptake increases proportional to population size.
Intervention implementation (MDA or vaccination)	Coverage levels, frequency and timing of intervention is pre-set.