Table 7.

Collagen fibril diameters (TEM) reported in OI bone.

⇒ Significantly smaller collagen fibril diameters measured in OI with clear differences in the four Sillence groups; smallest fibrils in lethal perinatal group and largest in milder cases (Stöss and Freisinger, 1993)

⇒ Collagen fibrils in OI type I adults consistently smaller in diameter than normal age matched subjects; OI fibrils 40–60 nm and normal controls 60–80 nm (Jones et al., 1984)

⇒ Smaller fibrils in 42 OI patients (all groups): severe Sillence II lethal perinatal with smallest mean diameter, 45 nm; mildest Sillence I autosomal dominant, 57 nm; and normal control mean diameter, 73 nm (Sarathchandra et al., 1999)

⇒ Mean fibril diameters in 12 OI patients, 60 nm, slightly larger than those in age and site matched controls, 53 nm (Cassella and Ali, 1992)

⇒ Collagen fibers, woven bone, Sillence II patient much smaller (diameters not given) than controls (Haebara et al., 1969)