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. 2020 Nov 11;11(4):1071–1094. doi: 10.1016/j.jcmgh.2020.11.005

Figure 8.

Figure 8

RNF43 mutations upstream of the RING domain confer resistance to DNA damage. (A) Viability of gastric organoids (n = 40) carrying different SNP variants of RNF43 after treatment with 5-fluorouracil (5-FU) or cisplatin. Fold change was calculated over untreated organoids. Horizontal lines represent the median values. Mann–Whitney test. (B) Representative images and quantification of cell colonies after γ-radiation. (n = 4). (C) Cell viability after treatment with 5-FU or cisplatin. Values were normalized over untreated cells (n = 4). Error bars indicate SD. ∗P ≤ .05, 2-tailed unpaired t test. Rel, relative.