Table 2.
List of Mutations Found in Human Gastric Tissue Samples
| Sample | RNF43 SNPs | RNF43 mutations | Other mutations | MSI status |
|---|---|---|---|---|
| Intestinal metaplasia | ||||
| IM1 | p.I47V p.R117H p.P686R |
– | APC p.A1471Gfs∗14 BRAF p.N581S |
|
| IM2 | p.I47V p.R117H |
– | APC p.R1445fs KRAS p.G13D |
|
| IM3 | p.R117H p.P686R |
– | – | |
| IM4 | – | – | ERBB4 p.L713V | |
| IM5 | p.I47V p.R117H p.L418M |
– | APC p.R1432X | |
| IM6 | p.R117H p.P686R |
– | – | |
| IM7 | p.R117H | – | – | |
| IM8 | p.I47V p.L418M p.P686R |
– | – | |
| IM9 | p.R117H p.L418M |
– | – | |
| IM10 | p.I47V | – | – | |
| IM11 | p.R117H | – | – | |
| IM12 | p.I47V p.R117H p.L418M |
– | – | |
| Intestinal-type gastric cancer | ||||
| GCi1 | p.I47V p.R117H p.L418M |
– | PTPRT p.P1075Rfs PIK3CA p.E542K TLR4 p.L10M |
|
| Gci2 | p.P686R | – | ERBB2 p.V842I | MSS |
| Gci3 | p.R117H p.P760P |
– | MDM2 amplification | |
| Gci4 | – | – | Sox2 p.E36G APC p.R1432X PREX2 p.L50V TP53 p.G66R |
|
| Gci5 | p.I47V p.R117H p.L418M |
– | TP53 p.E204X | |
| Gci6 | p.I47V p.L418M p.P686R |
– | TP53 p.R116Q TP53 p.Y88H CDKN2A p.Q50H |
|
| Gci7 | p.I47V p.R117H |
– | TLR4 p.L298V PTPRT p.E911G |
|
| Gci8 | p.I47V p.L418M p.P686R |
– | ARID1A p.P1467fs PTEN M134T TP53 R151H |
|
| Gci9 | WT | – | – | |
| Gci10 | p.I47V p.L418M |
– | – | MSS |
| Gci11 | p.I47V p.R343H p.L418M |
– | CDKN2A p.Q70X PTEN p.R130X TGFBR2 p.D405N |
|
| Gci12 | R117H | – | MSS | |
| Gci13 | p.I47V p.L418M |
– | TP53 p.G134E APC p.R1432X |
|
| Gci14 | p.I47V p.R117H |
p.R371R p.D628G |
CCND1 p.S257P | MSS |
| Gci15 | – | p.R132X | FBXW7 p.A508D RHOA p.Y42C ARID1A p.P2095fs |
MSI |
| Diffuse-type gastric cancer | ||||
| GCd1 | p.I47V p.L418M |
– | PREX2 p.R186Q | |
| GCd2 | p.I47V p.R117H p.P686R |
– | – | |
| GCd3 | – | p.R584fs | ERBB2 p.R678Q CDH1 p.E429G |
MSS |
| GCd4 | p.I47V p.L418M |
– | – | MSS |
| GCd5 | p.L418M | – | CDH1 p.D254H | |
| GCd6 | p.I47V p.L418M |
– | – | |
| GCd7 | – | p.R132X | TP53 p.R117M | MSS |
| GCd8 | p.I47V p.R343H p.L418M |
– | ARID1A p.R2158L CDH1 c.531+1G>T |
MSS |
| GCd9 | p.I47V p.L418M |
– | CDH1 p.E243K | MSS |
| GCd10 | p.I47V p.L418M |
– | KRAS p.G13D TP53 p.R150W PIK3CA p.N345K PIK3CA p.A1066V MTOR p.R2317I |
|
| GCd11 | p.P686R | – | – | |
| GCd12 | p.I47V p.L418M |
– | – | |
| GCd13 | p.I47V p.L418M |
– | PIK3CA p.H1047R | |
MSS, microsatellite stable.