Figure 14.

Intestine-specific FXR agonist activated ileal FXR in Atg5^F/Fbut not in Atg5^Δhepmice. (A) Scheme of the study using an intestine-specific FXR agonist, FEX. Solvent (1% dimethyl sulfoxide in corn oil) was given as the control. (B) Serum levels of ALT, AST, ALP, and TBA in mice after FEX treatment (n = 5–8). (C) Ileal expression of indicated genes was analyzed by qRT-PCR (n = 5). (D) TBA levels in the indicated compartments were measured (n = 5–8). Data are shown as means ± SE. Groups with different lowercase letters had significant differences (P < .05).