Figure 8.

Hepatic autophagy deficiency caused changes in the proportion of BA-metabolizing bacteria. (A) Venn diagram shows the number of bacterial species with BSH and/or 7α/β-dehydroxylation activity, which were disproportionate in Atg5^Δhep mice compared with the sex- and age- matched Atg5^F/F mice. (B) Disproportionate bacteria at the species level were segregated on the basis of gender of the mouse. Heatmap was generated, and values in the heatmap were mapped to colors using the minimum and maximum of each row independently. The hierarchical cluster of different species was constructed using one minus Pearson correlation method.