Table 1.
The Plasma Pharmacokinetic Parameters of IM Following Intravenous and Intratracheal Administration of Plain IM and IM-LPs to Rats
| Treatment | Cmax (μg/mL) | t1/2β (h) | AUC0–∞ (μg/mL·h) | MRT0→∞ (h) | Bioavailability (%) |
|---|---|---|---|---|---|
| Plain IM I.V. | —— | 3.15 ± 0.47 | 17.42 ± 1.94 | 3.82 ± 0.45 | —— |
| Plain IM I.T. | —— | 4.08 ± 1.01 | 14.54 ± 1.55 | 4.97 ± 0.72 | 83.46% |
| IM-LPs I.T. | 1.79 ± 0.19 | 12.68 ± 4.43* | 13.51 ± 1.54 | 10.38 ± 1.62* | 77.55% |
Notes: *Results are significantly different (P < 0.05), IM-LPs were compared with plain IM. Data represent mean ± SD, n = 6.