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. 2021 Feb 8;12:601404. doi: 10.3389/fphar.2021.601404

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Copyright © 2021 Husain, Zaidi, Singh, Guzman and Mehrotra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in the signal transducer and activator of transcription 3 (STAT3) phosphorylation in response to ocular hypertension and δ-opioid receptor agonist (SNC-121) treatment. The retina from normal, ocular hypertensive, and SNC-121 treated ocular hypertensive animals were collected at day 7, post hypertonic saline injection. Retina cryosections were immunostained using a selective anti-phosphoSTAT3 (Tyr 705) antibody and the nuclei were counterstained with DAPI. Green color indicates staining for phosphorylation of STAT3 and blue for the nuclei. There was no positive immunostaining when primary antibodies were omitted (not shown). Data shown here is a representation of at least four independent experiments. We have used four animals in each treatment group. OH Eyes; ocular hypertensive eyes; OH Eyes + SNC-121, ocular hypertensive eyes with SNC-121 treatment, bar size 20 µm.