TABLE 1.

Chemical compounds of Cordyceps spp. (mentioned here only those compounds which were tested in a laboratory) adapted from Olatunji et al. with permission (Originally some portion of Table 3) (Olatunji et al., 2018).

Compounds	Species	Mode of action	References
Palmitic acid	C. militaris (L.) Fr.	Inactive	Yoon et al. (2015)
Linoleic acid
Linoleic acid methyl ester
Cordytropolone	Cordyceps spp. BCC 1681	Antimalarial, cytotoxicity against KB, BC-1, and Vero cells lines	Seephonkai et al. (2001)
Helvolic acid	C. taii Z.Q. Liang and A.Y. Liu	Cytotoxicity against HeLa, HepG2, 95-D and SW1990 cell lines	Dou et al. (2013)
Cordycepiamide A	C. ninchukispora C.H. Su and H.H. Wang) G.H. Sung, J.M. Sung, Hywel-Jones and Spatafora	Anti-inflammatory	Reis et al. (2013)
Cordycepiamide B
Cordycepiamide C
Cordycepiamide D
N-(2-hydroxybenzyl)acetamide
(-)-Syringaresinol
Cordycerebroside A	C. militaris (L.) Fr.	Anti-inflammatory	Chiu et al. (2016b)
Soyacerebroside I
Glucocerebroside
Ergosterol peroxide	C. cicadae S.Z. Shing	Anti-inflammatory, renoprotective	Kuo et al. (2003)
Ergosta-4,6,8 (14),22-tetraen-3-one	C. sinensis (Berk.) Sacc.	Antitumor	Bok et al. (1999)
Jiangxienone	C. jiangxiensis Z.Q. Liang, A.Y. Liu & Yong C. Jiang	Cytotoxicity against SGC-7901 and A549 cell lines	Zhan et al. (2005)
H1-A	C. sinensis (Berk.) Sacc.	Renoprotective	Yang et al. (2003)
Cordyheptapeptide A	Cordyceps spp. BCC 16173	Cytotoxicity against KB, BC, NCI-H187, and Vero cells lines	Isaka et al. (2007b)
Cordyheptapeptide B	Cordyceps spp. BCC 16176	Cytotoxicity against KB, BC, NCI-H187, and Vero cells lines
Cordycommunin	Ophiocordyceps Communis Hywel-Jones and Samson	Anti-mycobacterial	Haritakun et al. (2010)
Beauvericin J	C. cicadae S.Z. Shing	Cytotoxicity against HepG2 and HepG2/ADM cell lines	Wang et al. (2004)
Beauvericin
Beauvericin A
Beauvericin B
Beauvericin E
Cordyceamide A	C. sinensis (Berk.) Sacc.	Cytotoxicity against L929, A375, and Hela cell lines	Jia et al. (2009)
Cordyceamide B
Cycloaspeptide A		Cytotoxicity against HeLa and MCF-7 cell lines	Zhang et al. (2009)
Cycloaspeptide C
Cycloaspeptide F
Cycloaspeptide G
Cordycepin		Neuroprotection, anti-metastatic, anti-platelet aggregation, anti-inflammatory activity, anti-cancer	Yu H M et al. (2006)
N6-hydroxyethyl-adenosine	C. pruinosa Petch	Anti-inflammatory, Ca2+ antagonistic	Meng et al. (2015)
Guanosine	C. sinensis (Berk.) Sacc.	Immunomodulatory	Yu L et al. (2006)
CordysininB		Anti-inflammatory	Yang et al. (2011)
Dimethylguanosine		Antioxidant and HIV-1 protease	Jiang et al. (2011)
Ergosterol		Anti-inflammatory, anti-fibrotic	Nallathamby et al. (2015)
Ergosteryl-3-O-β-D-glucopyranoside		Anti-inflammatory, antioxidant	Bok et al. (1999)
5α,8α-epidioxy-22E-ergosta-6,9-(11)-22-trien-33β-ol		Cytotoxic against HL-60 cell line	Matsuda et al. (2009)
5α,6α-epoxy-5α-ergosta-7,22-dien-3β-ol
5α,8α-epidioxy-24(R)-methylcholesta-6,22-dien-3β-D- glucopyranoside		Antitumor	Bok et al. (1999)
Cardinalisamide A	C. cardinalis G.H. Sung & Spatafora	Antitrypanosomal	Umeyama et al. (2014)
Cardinalisamide B
Cardinalisamide C
Cicadapeptin I	C. heteropoda Kobayasi	Antibacterial and antifungal	Krasnoff et al. (2005)
Cicadapeptin II
Cordycepsidone A	C. dipterigena Berk. and Broome	Antifungal	Varughese et al. (2012)
Cordycepsidone B
Cyclo (L-Pro-L-Val)	C. sinensis (Berk.) Sacc.	Antioxidant, anti-inflammatory	Yang et al. (2011)
Cyclo (L-Phe-L-Pro)
Cyclo (L-Pro-L-Tyr)
Cordycepoid A	C. bifusispora O.E. Erikss.	Inactive	Lu et al. (2013)
Cordysinin A	C. sinensis (Berk.) Sacc.	Anti-inflammatory, antioxidant	Yang et al. (2011)
Flazin
Perlolyrine
Cordyformamide	C. brunnearubra BCC 1395	Antimalarial	Isaka et al. (2007a)
Deacetylcytochalasin C	C. taii Z.Q. Liang and A.Y. Liu	Cytotoxicity against 95-D, A-549, and HL-7702 cell lines	Li et al. (2015)
Zygosporin D		Cytotoxicity against 95-D, A-549, and HL-7702 cell lines
Cordypyridone A	C. nipponica Kobayasi	Antimalarial	Isaka et al. (2001)
Cordypyridone B
Cordypyridone C
Cordypyridone D
1-Dehydroxycordypyridone A
3′,4′,7-Trihydroxyisoflavone	C. sinensis (Berk.) Sacc.	Antioxidant	Yang et al. (2011)
Diadzein		Antioxidant, anti-inflammatory
Rugulosin	C. formosana Kobayasi & Shimizu	Cytotoxicity against CHO cell line	Lu et al. (2014)
Skyrin
6′-O-desmethylES-242–4	Cordyceps spp. BCC 16173	Antimalarial	Isaka et al. (2007b)
Annullatin A	C. annullata Kobayasi & Shimizu	Cannabinoid receptors agonist	Asai et al. (2012)
Annullatin B
Annullatin C
Annullatin D
Annullatin E
Erythrostominone	C. unilateralis (Tul.) Sacc.	Antimalarial, cytotoxicity against BC, KB, and Vero cell lines	Kittakoop et al. (1999)
Deoxyerythrostominone
4-O-methyl-erythrostominone
Epierythrostominol
Deoxyerythrostominol
Cordycepol	C. ophioglossoides (T. ophioglossoides) (Ehrh.) link	Cytotoxicity against HeLa and HepG2 cell lines	Sun et al. (2013)
Cordycepol B		Inactive
Cordycepol C		Cytotoxicity against HeLa and HepG2 cell lines
Cordycol
Ophicordin	C. sinensis (Berk.) Sacc.	Antifungal	Kneifel et al. (1977)
Terreusinone A	C. gracilioides Kobayasi	Protein tyrosine phosphatases inhibitor	Wei et al. (2015)
Pinophilin C
CryptosporioptideA
Furancarboxylicacid	C. sinensis (Berk.) Sacc.	Anti-inflammatory, antioxidant	Yang et al. (2011)
Hydroxy-2-methyl-4-pyrone
Bassiamide A (KTH-7-1)	C. bassiana Z.Z. Li, C.R. Li, B. Huang and M.Z. Fan	Antiproliferative against C6 glioma cell	Kim J H et al. (2015)
Bassiamate (KTH-7-2)
IPr-PEPhenol (KTH-13)
KTH-15–2
KTH-17
4-Quinolinol		Anti-inflammatory	Kim T W et al. (2014)
1-Naphthol