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. 2020 Nov 22;11(4):999–1021. doi: 10.1016/j.jcmgh.2020.11.006

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Loss of mucus granules and ultrastructural damage to theca in goblet cells of CTα^IKO mice. (A) Representative Alcian blue/periodic acid–Schiff staining in colons from control mice and CTα^IKO mice. (B) Representative transmission electron micrographs of goblet cell theca in the colons of control mice and CTα^IKO mice. (C) Pathology score for goblet cell depletion in the colons of control mice and CTα^IKO mice (n = 10–11/group). (D) The mRNA abundance of Muc2, Tff3, and Agr2 in the colons of control mice and CTα^IKO mice (n = 10/group). (E) The mRNA abundance of enteroendocrine cell markers in the colons of control mice and CTα^IKO mice (n = 5/group). (F) The mRNA abundance goblet cell maturation factors in the colons of control mice and CTα^IKO mice (n = 5/group). Values are means ± SEM. ∗P < .05, ∗∗P < .01, and ∗∗∗P < .001, ∗∗∗∗P < .0001.