Table 1.

Acid-loading and acid-extruding ion channels, their associated ions and effects on intracellular pH.

	channel	ion(s) moved into the cell	ion(s) moved out of the cell	intracellular pH
acid loaders	AE1-3	Cl−	$\text{HC}{\text{O}}_3^{\hspace{0.17em}-}$	decrease
	NBCe1-A (renal proximal tubule)	—	$\text{HC}{\text{O}}_3^{\hspace{0.17em}-}/\mathrm{N}{\text{a}}^{+}$	decrease
acid extruders	V-ATPases	—	H+	increase
	SLC9/NHE	Na+	H+	increase
	NBCe1-B (pancreatic duct)	$\text{HC}{\text{O}}_3^{\hspace{0.17em}-}/\mathrm{N}{\text{a}}^{+}$	—	increase
	NBCe1-C (neuron)	$\text{HC}{\text{O}}_3^{\hspace{0.17em}-}/\mathrm{N}{\text{a}}^{+}$	—	increase
	NBCn1/2	$\text{HC}{\text{O}}_3^{\hspace{0.17em}-}/\mathrm{N}{\text{a}}^{+}$	—	increase
	NDCBE	$\text{HC}{\text{O}}_3^{\hspace{0.17em}-}/\mathrm{N}{\text{a}}^{+}$	Cl−	increase