Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 8;11:630222. doi: 10.3389/fphar.2020.630222

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Xia, Wang, Guo, Wu, Huang and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Catalpol improved OGD/R induced neuronal injury by upregulating miR-142 in vitro. BV-2 cells were transfected with antagomiR-142 in the presence with CTP (0, 5 and 10 μM), following subjected to OGD/R. (A) The expression of miR-142 was determined by qRT-PCR. (B) Cell viability was assessed using CCK-8 assay. (C and D) Apoptosis was measured using flow cytometry. (E) ROS generation was calculated using 2,7-DCF-DA staining kit. (F and G) The contents of MDA and SOD were measured by commercial kits. (H–K) The inflammatory cytokines including TNF-α, IL-1β, IL-6 and IL-10, were evaluated by ELISA assays. Data represent the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01 vs. OGD/R group; ##p < 0.01 vs. OGD/R + CTP group.