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. 2021 Feb 17;17:533–543. doi: 10.2147/NDT.S293614

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© 2021 Qian et al.

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Idebenone ameliorates brain injury in VD rats. (A) The escape latency test examined by MWM test. (B) The spatial memory ability of rats tested by platform crossing experiment. (C) Swimming speed of rats. (D) The concentrations of oxidative stress- and inflammation-related indexes in hippocampus detected by ELISA. (E) The neuronal damage in the hippocampal cortex examined by HE staining. (F) The neuronal damage in hippocampal CA1 area of rats measured by Nissl staining. N = 10. All experiments were repeated three times independently. The results were shown as mean ± SEM or representative pictures. Data in panels B/D/F were analyzed by one-way ANOVA, and data in panels A/C were analyzed by two-way ANOVA. *p < 0.05, vs the sham; #p < 0.05, vs the VD.