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. 2021 Feb 17;17:533–543. doi: 10.2147/NDT.S293614

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© 2021 Qian et al.

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Inhibition of miR-216a attenuates the improvement of Idebenone on learning and spatial memory abilities in VD rats. (A) The differentially expressed miRs in hippocampus of VD group and Idebenone group screened by microarray analysis. (B) Detection of miR-216a expression in VD rats by RT-qPCR. (C) The learning ability of rats was detected by escape latency test. (D) The spatial memory ability of rats was detected by platform crossing experiment. (E) The changes of swimming speed. N = 10. All the experiments were repeated three times independently. The results showed that the average value was ± SEM. Unpaired t-test was used for comparison in panel B/D, and two-way ANOVA was used for comparison in panels C/E. *p < 0.05, vs Lv-NC; #p < 0.05, vs sham-operated rats.