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. 2021 Feb 17;17:533–543. doi: 10.2147/NDT.S293614

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© 2021 Qian et al.

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Inhibition of miR-216a weakens the inhibitory effect of Idebenone on neuroinflammation and oxidative stress in VD rats. (A) The miR-216a expression in hippocampus of rats after injection determined by RT-qPCR. (B) The concentration of inflammation- and oxidative stress-related indicators in the hippocampus examined by ELISA. (C) The neuronal damage in the hippocampal cortex evaluated by HE staining. (D) The damage of neurons observed by Nissl staining. N = 10. All the experiments were repeated three times independently. The results showed that the average value was ± SEM. Unpaired t-test was used for comparison between two groups. *p < 0.05, vs Lv-NC.