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. 2021 Feb 17;14:1117–1129. doi: 10.2147/OTT.S289241

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© 2021 Su et al.

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CircDNM3OS regulated MORC2 expression by sponging miR-145-5p in CCA cells. (A) Schematic diagram of the complementary sequence between MORC2 and miR-145-5p. (B, C) Dual-luciferase reporter assay was performed to verify the relationship between MORC2 and miR-145-5p. (D) Analysis of the relative expression of MORC2 mRNA in CCA tissues by qRT-PCR. (E, F) Relative protein level of MORC2 in CCA tissues and cells was analyzed by Western blotting. (G) The correlation between MORC2 mRNA and miR-145-5p or circDNM3OS in CCA tissues was estimated by Pearson’s correlation analysis. (I) Relative protein level of MORC2 in HuCCT1 and HuH28 cells transfected with miR-NC, miR-145-5p, miR-145-5p+pcDNA, or miR-145-5p+MORC2 was determined by Western blotting. (J) Relative protein level of MORC2 in HuCCT1 and HuH28 cells transfected with si-NC, si-circDNM3OS, si-circDNM3OS+in-miR-NC, or si-circDNM3OS+in-miR-145-5p was detected using Western blotting. *P < 0.05.