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. 2021 Feb 17;14:413–428. doi: 10.2147/JIR.S297081

Figure 7.

Figure 7

LncRNA4344 (NONRATT004344.2), rno-miR-138-5p, and NLRP3 ceRNA network. (A) miRNAs that are interact with both lncRNA4344 and NLRP3 are shown in the Venn diagram. (B) The table shows the details of the miRNAs targeted by both lncRNA4344 and NLRP3 in the miRDB database. (C) The regulatory relationship map among lncRNA4344, miR-138-5p, and NLRP3. (D) A firefly luciferase reporter containing either wild‐type or mutant lncRNA4344 was cotransfected into A549 cells with miR‐NC or miR‐138-5p mimics. (E). A firefly luciferase reporter containing either wild‐type or mutant NLRP3 was cotransfected into A549 cells with miR‐NC or miR‐138-5p mimics. The luciferase activity of miR‐NC‐transfected cells was supposed to be 1. Each experiment was repeated three times. *p < 0.05; NS, no statistically significant difference.

Abbreviations: qRT-PCR, quantitative real-time reverse transcriptase-PCR; NLRP3, Nod-like receptor protein-3; IL‐1β, interleukin (IL)‐1β; IL‐6, interleukin (IL)‐6; IL-18, interleukin (IL)-18; LPS, lipopolysaccharides; TNF-α, tumor necrosis factor-α.