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. 2021 Feb 17;14:413–428. doi: 10.2147/JIR.S297081

Table 3.

The Hub Nodes in the Protein-Protein Interaction Network According to the Score of Network Topology Property Indicators

Rank Node_Name Degree EPC EcCentricity Closeness Radiality Betweenness
1 Tnf 35 86.702 0.08918 81.26349 12.58823 13682.09
2 Jun 23 86.702 0.08107 72.18337 12.33418 3286.734
3 Atf3 21 86.702 0.08107 70.08456 12.24086 2937.374
4 IL1b 19 86.702 0.08107 69.00956 12.25641 1016.724
5 Nfkbia 17 86.702 0.08107 67.12504 12.18901 730.6439
6 Egr1 16 86.702 0.08107 68.88337 12.30307 3120.393
7 Zfp36 14 86.702 0.08107 66.7917 12.25641 1685.765
8 Dusp1 14 86.702 0.08107 65.33456 12.14754 676.7042
9 Rela 13 86.526 0.08107 64.40837 12.14754 667.0527
10 Nfkb2 12 86.617 0.08107 62.83456 12.04384 332.3751
11 Junb 12 86.702 0.07431 59.70678 11.91423 2575.122
12 Irf1 12 86.702 0.08107 62.86075 12.04384 498.7108
13 Ppp1r15a 11 85.836 0.07431 58.68416 11.83128 2288.497
14 Ptprc 11 86.702 0.08107 59.73575 11.93497 671.6867
15 Igf1 10 86.471 0.08107 64.18337 12.19938 3147.178
16 Nfkbiz 10 86.322 0.08107 62.80004 12.16827 3664.288
17 Ptpn11 9 85.634 0.08107 59.23575 11.94015 938.0699
18 Ier2 9 86.27 0.07431 56.69131 11.78461 577.7848
19 IL1a 8 86.31 0.08107 57.57742 11.87794 49.35081
20 Hnrnpa1 8 39.866 0.07431 38.554 10.12035 841.2823
21 Klf6 8 86.41 0.07431 56.6175 11.77424 34.7899
22 Map3k8 8 85.95 0.08107 58.81789 11.97126 1494.478
23 Nfe2l2 8 85.165 0.08107 60.44408 12.01792 831.0779
24 Nlrp3 7 85.119 0.08107 57.51075 11.87275 1074.296
25 Snrpa 7 39.897 0.0686 39.47342 10.35366 1497.442
26 Cwc25 7 39.353 0.0686 36.427 9.85594 420.5
27 Crem 7 85.706 0.07431 54.01988 11.64981 360.8152
28 Cish 7 80.231 0.08107 58.48575 11.93497 1814.863
29 Fbxo27 7 76.674 0.07431 48.42821 11.32837 528.1243
30 Sgk1 6 83.203 0.07431 55.45916 11.78461 848.2421

Abbreviation: EPC, edge percolated component.