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. Author manuscript; available in PMC: 2021 Feb 22.
Published in final edited form as: Cell Rep. 2020 Dec 29;33(13):108566. doi: 10.1016/j.celrep.2020.108566

Figure 1. Diverse Epithelial and Stromal Cell Types Identified by scRNA-Seq in Mammary Glands.

Figure 1.

(A) scRNA-seq experimental setup. Freshly dissociated epithelial and stromal cells were analyzed without FACS enrichment.

(B) t-SNE plot showing epithelial and stromal clusters identified based on characteristic markers.

(C and D) Epithelial (C) and stromal (D) cells subsetted and reclustered.

(E and F) Expression of canonical markers of epithelial (E) and stromal (F) cell types.

(G) Heatmap of cell type-specific gene signatures. See also Table S1.

Abbreviations: Myoep, myoepithelial; HS, hormone-sensing; AV, alveolar; LP, luminal progenitors; Fibro, fibroblasts; pan-VL, pan-vascular/lymphatic cells; VE, vascular endothelial cells; P, pericytes; LE, lymphatic endothelial cells; Im, immune cells; My, myeloid cells; DC, dendritic cells; Mac, macrophages; Ma, Ma macrophages, Mb, Mb macrophages; Ly, lymphocytes; NK, natural killer cells; T, T cells; B, B cells.