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. Author manuscript; available in PMC: 2021 Feb 28.
Published in final edited form as: Nat Cell Biol. 2020 Aug 31;22(9):1049–1055. doi: 10.1038/s41556-020-0564-2

Extended Data Fig. 5. Cartoon scheme of proposed mechanism.

Extended Data Fig. 5

Wounding activates Duox to produce H2O2 and causes hypotonic (Hypo) shock, which leads to release of PUFAs (including AA). H2O2 reacts with Fe2+ to generate HO∙ by Fenton chemistry. HO∙ reacts with PUFAs/AA to generate long-chain lipid ROS (PUFA-OO∙, PUFA-OOH) that further promote lipid peroxidation, and activate Alox5a to produce leukocyte chemoattractants. If lipid peroxidation slips out of control, it may cause cell death.