TABLE 4.
Subanalysis of patients with/without migraine prior to IIH diagnosis and with/without MOH
| Mean (SD) [95% CI], unless otherwise specified | Baseline | 3 months | 6 months | 9 months | 12 months |
|---|---|---|---|---|---|
| Patients with migraine diagnosis prior to IIH | n = 28 | n = 28 | n = 28 | n = 27 | n = 25 |
| MmsHD | 15.3 (4.3) | 7.5 (4.1) | 5.7 (4.4) | 7 (6.1) | 5.0 (4.1) |
| MmsHD change | −7.6 (3.1) [−6.6, −9.0] | −9.5 (4.1) [−8.0, −11.1] | −7.8 (4.2) [−6.2, −9.8] | −9.9 (3.6) [−8.2, −11.2] | |
| p‐value | <0.001 | <0.001 | <0.001 | <0.001 | |
| MHD | 29.6 (1.1) | 22.5 (8.0) | 19.6 (8.7) | 20.6 (9.2) | 16.6 (9.7) |
| MHD change | −7.1 (7.6) [−4.1, −10.0] | −10.0 (8.6) [−6.7, −13.3] | −8.5 (9) [−5.5, −12.6] | −13.0 (9.7) [−8.4, −16.3] | |
| p‐value | <0.001 | <0.001 | 0.001 | <0.001 | |
| Patients without migraine diagnosis prior to IIH | n = 27 | n = 27 | n = 26 | n = 24 | n = 23 |
| MmsHD | 16.9 (4.9) | 7.3 (3.8) | 6.3 (4.6) | 5.6 (5.3) | 4.4 (3.8) |
| MmsHD change | −9.6 (4.5) [−7.8, −11.4] | −10.7 (5.4) [−8.5, −12.8] | −11.5 (4.4) [−9.7, −13.5] | −11.9 (4.2) [−10.0, −13.8] | |
| p‐value | <0.001 | <0.001 | <0.001 | <0.001 | |
| MHD | 28.3 (−2.9) | 20.3 (8.5) | 17.5 (9.6) | 17.9 (9.3) | 15.3 (10.0) |
| MHD change | −8.9 (8.5) [−5.0, −11.0] | −11.1 (8.9) [−7.0, −14.5] | −10.7 (9.3) [−7.4, −14.2] | −13.1 (9.4) [−9.6, −17.8] | |
| p‐value | <0.001 | 0.001 | 0.001 | <0.001 | |
| Patients with MOH | n = 27 | n = 27 | n = 25 | n = 25 | n = 24 |
| MmsHD | 16.4 (4.7) | 7.8 (3.7) | 6.0 (4.3) | 6.2 (5) | 4.5 (3.4) |
| MmsHD change | −8.5 (3.7) [−7.2, −10.1] | −10.4 (4.8) [−8.6, −12.4] | −9.4 (3.8) [−7.9, −11.3] | −11.0 (3.8) [−9.1, −12.6] | |
| p‐value | <0.001 | <0.001 | <0.001 | <0.001 | |
| MHD | 28.3 (2.9) | 20.4 (8.5) | 18.8 (9.2) | 19.6 (9.7) | 16.4 (10.5) |
| MHD change | −7.6 (7.5) [−4.3, −10.2] | −9.9 (8.7) [−5.9, −13.1] | −8.7 (9.3) [−4.7, −12.3] | −12.0 (10.0) [−7.6, −16.0] | |
| p‐value | <0.001 | <0.001 | 0.002 | <0.001 | |
| Patients without MOH | n = 28 | n = 28 | n = 27 | n = 26 | n = 24 |
| MmsHD | 15.7 (4.7) | 7.0 (4.2) | 6 (4.7) | 5.9 (5.6) | 5.0 (4.4) |
| MmsHD change | −8.7 (4.3) [−7.0, −10.3] | −9.7 (4.7) [−7.8, −11.5] | −9.6 (5.4) [−7.6, −12.0] | −10.6 (4.2) [−8.9, −12.4] | |
| p‐value | <0.001 | <0.001 | <0.001 | <0.001 | |
| MHD | 29.6 (1.1) | 22.4 (8.1) | 18.4 (9.1) | 18.5 (8) | 15.5 (9.3) |
| MHD change | −8.3 (8.7) [−4.3, −10.2] | −11.2 (8.8) [−7.7, −14.7] | −11.2 (7.8) [−8.0, −14.3] | −14.1 (9.0) [−10.3, −17.9] | |
| p‐value | <0.001 | <0.001 | 0.002 | <0.001 | |
| Patients without prior migraine and without MOH | n = 14 | n = 14 | n = 13 | n = 12 | n = 12 |
| MmsHD | 17.1 (5.2) | 6.8 (4.7) | 6.2 (5.1) | 4.8 (4.2) | 5.3 (4.9) |
| MmsHD change | −10.3 (5.0) [−7.4, −13.2] | −10.9 (5.9) [−7.3, −14.5] | −12.1 (4.8) [−9.5, −15.5] | −12.1 (4.6) [−9.2, −15.0] | |
| p‐value | <0.001 | <0.001 | <0.001 | <0.001 | |
| MHD | 29.6 (0.7) | 21.2 (8.8) | 16.2 (9.2) | 16.9 (6.9) | 16.8 (10.6) |
| MHD change | −10.6 (10.0) [−3.4, −13.4] | −13.5 (9.0) [−8.0, −19.0] | −12.2 (6.8) [−8.5, −17.2] | −12.9 (10.5) [−6.3, −19.6] | |
| p‐value | 0.008 | 0.003 | 0.005 | 0.008 |
Data presented as Mean (SD) [95% Confidence Interval], unless otherwise specified. Statistical tests represent paired t test for MmsHD and Wilcoxon signed ranks test for MHD for the 3, 6, 9, and 12 months end points compared to baseline.
Abbreviations: CI, Confidence interval; IIH, idiopathic intracranial hypertension; MHD, monthly total headache days; MmsHD, monthly moderate/severe headache days; MOH, medication overuse headache.