Table 1.
Association between genetically predicted obesity‐related traits and risk of rheumatoid arthritis in a primary analysis excluding SNPs located in the HLA region*
| Parameter, MR approach | SNPs at P < 5 × 10−9 (primary + secondary GWAS hits) | SNPs at P < 5 × 10−9 (primary GWAS hits) | ||||
|---|---|---|---|---|---|---|
|
OR (95% CI) |
P | P for heterogeneity or pleiotropy |
OR (95% CI) |
P | P for heterogeneity or pleiotropy | |
| BMI (n = 790/660) | ||||||
| Random‐effects IVW | 1.22 (1.09–1.37) | 6.1 × 10−4 | <0.001 | 1.21 (1.08–1.37) | 1.6 × 10−3 | <0.001 |
| MR‐Egger | 1.13 (0.83–1.54) | 0.43 | 0.60 | 1.11 (0.81–1.54) | 0.51 | 0.57 |
| MR‐PRESSO (detected outliers 1/NA) | 1.20 (1.07–1.34) | 1.5 × 10−3 | – | 1.21 (1.08–1.37) | 1.7 × 10−3 | – |
| WHR (n = 369/310) | ||||||
| Random‐effects IVW | 0.98 (0.84–1.14) | 0.78 | <0.001 | 0.96 (0.82–1.13) | 0.62 | <0.001 |
| MR‐Egger | 0.91 (0.60–1.37) | 0.66 | 0.71 | 0.96 (0.62–1.49) | 0.85 | 0.99 |
| MR‐PRESSO (detected outliers 2/2) | 0.93 (0.81–1.07) | 0.31 | – | 0.92 (0.79–1.08) | 0.32 | – |
| WHRadjBMI (n = 441/335) | ||||||
| Random‐effects IVW | 0.90 (0.79–1.04) | 0.15 | <0.001 | 0.85 (0.73–0.98) | 0.02 | <0.001 |
| MR‐Egger | 0.92 (0.68–1.25) | 0.60 | 0.90 | 0.99 (0.71–1.38) | 0.95 | 0.31 |
| MR‐PRESSO (detected outliers 5/3) | 0.86 (0.77–0.97) | 0.01 | – | 0.83 (0.72–0.94) | 5.6 × 10−3 | – |
*
N values (number of single‐nucleotide‐polymorphisms [SNPs]) for body mass index (BMI), waist‐to‐hip ratio (WHR), and WHR adjusted for BMI (WHRadjBMI) and numbers of detected outliers in the Mendelian randomization pleiotropy residual sum and outlier (MR‐PRESSO) analyses are for the analysis of primary + secondary genome‐wide association study (GWAS) hits/analysis of primary SNPs only. OR = odds ratio; 95% CI = 95% confidence interval; IVW = inverse variance–weighted method; NA = not applicable.