Table 2.
Association between genetically predicted obesity‐related traits and risk of rheumatoid arthritis in a sensitivity analysis excluding genetic instruments in the HLA region or associated with confounding traits*
| Parameter, MR approach | SNPs at P < 5 × 10−9 (primary + secondary GWAS hits) | Primary SNPs at P < 5 × 10−9 | ||||
|---|---|---|---|---|---|---|
|
OR (95% CI) |
P | P for heterogeneity or pleiotropy |
OR (95% CI) |
P | P for heterogeneity or pleiotropy | |
| BMI (n = 696/582) | ||||||
| Random‐effects IVW | 1.27 (1.12–1.45) | 2.4 × 10−4 | <0.001 | 1.28 (1.11–1.46) | 4.5 × 10−4 | <0.001 |
| MR‐Egger | 1.44 (0.94–2.22) | 0.10 | 0.55 | 1.44 (0.88–2.33) | 0.14 | 0.62 |
| MR‐PRESSO (detected outliers 1/2) | 1.24 (1.10–1.41) | 6.9 × 10−4 | – | 1.30 (1.14–1.49) | 1.2 × 10−4 | – |
| WHR (n = 307/255) | ||||||
| Random‐effects IVW | 1.05 (0.87–1.26) | 0.61 | <0.001 | 1.03 (0.86–1.24) | 0.75 | 2.0 × 10−3 |
| MR‐Egger | 0.94 (0.54–1.63) | 0.82 | 0.68 | 1.13 (0.61–2.11) | 0.70 | 0.76 |
| MR‐PRESSO (detected outliers 2/1) | 1.02 (0.87–1.21) | 0.77 | – | 1.05 (0.88–1.26) | 0.58 | – |
| WHRadjBMI (n = 348/258) | ||||||
| Random‐effects IVW | 0.92 (0.78–1.09) | 0.34 | <0.001 | 0.85 (0.71–1.01) | 0.06 | 0.01 |
| MR‐Egger | 0.98 (0.66–1.46) | 0.93 | 0.74 | 1.19 (0.72–1.97) | 0.49 | 0.16 |
| MR‐PRESSO (detected outliers 4/2) | 0.85 (0.74–0.97) | 0.02 | – | 0.80 (0.68–0.94) | 0.01 | – |
*
N values (number of SNPs) for BMI, WHR, and WHRadjBMI and numbers of detected outliers in the MR‐PRESSO analyses are for the analysis of primary + secondary GWAS hits/analysis of primary SNPs only. See Table 1 for definitions.