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. 2021 Feb 19;38(5):655–664. doi: 10.1089/neu.2020.7226

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© Ayman H. Faroqi et al., 2020; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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FIG. 3. — Monitoring eATP changes in pmeLUC-CCI model. (A) Representative images of IVIS imaging before and after CCI surgery. First and third rows (pre-sham or pre-CCI) represent three time points during the baseline acquisition period (pre-surgery), showing a gradual increase in ATP signal. Second and fourth rows (post-surgery) represent three time points taken after surgery. Increased signal is present at the site of impact in CCI animals. (B) Comparison of bioluminescence signal post-surgery shows a significant difference in eATP levels between sham (n = 7) and CCI (n = 8) groups (p = 0.0008; unpaired t test). (C) APT102 apyrase treatment prevents increase in pmeLUC activity. Representative image of vehicle- and APT102-treated animals before and after CCI surgery. (D) Comparison of bioluminescent signal shows a significant difference between vehicle- (n = 4) and apyrase-treated (n = 4) animals receiving CCI (p = 0.0483; unpaired t test). ATP, adenosine triphosphate; CCI, controlled cortical impact; eATP, extracellular ATP; IVIS, in vivo imaging system; Max, maximum; Min, minimum.