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. 2021 Feb 22;16:11. doi: 10.1186/s13024-021-00422-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Disease subtype-specific interactors bound to high-density prion protein oligomers. A) The experimental setup for carrying out the co-immunoprecipitation of HDPs and their potential interactors. B) Numerical Venn-diagram showing the overlap of subtype-specific HDP interactors. pF12-pF17: pools of high-density fractions 12–17 from multiple patient samples. IP-F-Con: high-density PrP (HDP) interactors in control HDFs pools from 12 to 17 (collectively), IP-F-spAD: HDP interactors in spAD HDFs pools from 12 to 17, IP-F-rpAD: HDP interactors in rpAD HDFs pools from 12 to 17, IP-F-MM1: HDP interactors in sCJD-MM1 HDFs pools from 12 to 17, IP-F-VV2: HDP interactors in sCJD-VV2 HDFs pools from 12 to 17, IP-F-MM2: HDP interactors in sCJD-MM2 HDFs pools from 12 to 17