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. 2021 Jan 29;4(4):e202000900. doi: 10.26508/lsa.202000900

Figure 1. TLS pathways for replication through UV lesions.

Figure 1.

(A) TLS pathways for replication through cyclobutane pyrimidine dimers (CPDs). Polη replicates through CPDs in an error-free manner. Polθ functions in inserting nts opposite the 3′T or 3′C of a CPD in the error-prone TLS pathways dependent upon Polκ or Polζ for extension of synthesis. As a scaffolding component, Rev1 functions together with Polη or Polκ, and Polλ functions together with Polζ. (B) TLS pathways for replication through (6-4)PPs. Polθ extends synthesis from the nts inserted by Polη or Polι opposite the 3′T or 3′C of the (6-4) photoproduct and these pathways promote error-prone TLS. After nt insertion opposite the (6-4) lesion by Polλ, Polζ would extend synthesis from the nt inserted by Polλ. The Polλ/Polζ pathway conducts error-free TLS through (6-4) PPs. The thickness of the arrows depicts the relative contribution of TLS Pols to lesion bypass.