TABLE 1.
The frequency of HLA‐B serotypes in the COVID‐19 patient group, the Hong Kong Chinese Cord Blood Registry (HKCCBR), and the Hong Kong Red Cross Blood Transfusion Service (HKRCBTS) blood donors
| Serotype | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| COVID‐19 patients (n = 190) | HKCCBR (n = 3892) | HKRCBTS blood donors (n = 294) | ||||||||||||
| Count | Frequency | Count* | Frequency | OR | 95% CI | p‐value | Corrected p‐value | Count | Frequency | OR | 95% CI | p‐value | Corrected p‐value | |
| B5 | 15 | 3.95% | 520 | 6.68% | 0.57 | 0.34–0.97 | 0.033 | ns | 26 | 4.42% | / | / | 0.870 | / |
| B7 | 8 | 2.11% | 123 | 1.58% | / | / | 0.400 | / | 9 | 1.53% | / | / | 0.618 | / |
| B8 | 1 | 0.26% | 23 | 0.30% | / | / | 1.000 | / | 1 | 0.17% | / | / | 1.000 | / |
| B12 | 1 | 0.26% | 143 | 1.84% | 0.14 | 0.02–1.01 | 0.015 | ns | 5 | 0.85% | / | / | 0.413 | / |
| B13 | 38 | 10.00% | 733 | 9.42% | / | / | 0.719 | / | 59 | 10.03% | / | / | 1.000 | / |
| B15 | 69 | 18.16% | 1217 | 15.63% | / | / | 0.194 | / | 108 | 18.37% | / | / | 1.000 | / |
| B16 | 22 | 5.79% | 556 | 7.14% | / | / | 0.357 | / | 44 | 7.48% | / | / | 0.361 | / |
| B17 | 30 | 7.89% | 673 | 8.65% | / | / | 0.708 | / | 46 | 7.82% | / | / | 1.000 | / |
| B22 | 43 | 11.32% | 540 | 6.94% | 1.71 | 1.23–2.38 | 0.002 | 0.032 | 42 | 7.14% | 1.66 | 1.06–2.59 | 0.027 | ns |
| B27 | 4 | 1.05% | 202 | 2.60% | / | / | 0.064 | / | 18 | 3.06% | 0.34 | 0.11–1.00 | 0.047 | ns |
| B35 | 13 | 3.42% | 259 | 3.33% | / | / | 0.883 | / | 19 | 3.23% | / | / | 0.856 | / |
| B40 | 73 | 19.21% | 1416 | 18.19% | / | / | 0.634 | / | 105 | 17.86% | / | / | 0.611 | / |
| B46 | 56 | 14.74% | 1090 | 14.00% | / | / | 0.705 | / | 85 | 14.46% | / | / | 0.926 | / |
| B48 | 6 | 1.58% | 147 | 1.89% | / | / | 0.846 | / | 11 | 1.87% | / | / | 0.807 | / |
| B67 | 1 | 0.26% | 14 | 0.18% | / | / | 0.511 | / | 1 | 0.17% | / | / | 1.000 | / |
Abbreviations: n, number of subjects; OR, Odds ratio; 95% CI, 95% confidence interval; corrected p value, p value after Bonferroni correction.
a
All the HLA‐B alleles belonging to the same serotype were counted.