TABLE 2.
Relationship of HLA‐B serotypes with the presence of symptoms, lymphopenia, and disease severity in COVID‐19 patients
| Serotype | Presence of symptoms | Lymphopenia | Disease severity* | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Yes (n = 160) | No (n = 21) | Yes (n = 60) | No (n = 121) | Mild/moderate (n = 150) | Severe/critical (n = 10) | ||||||||||
| Count | Frequency | Count | Frequency | p‐value | Count | Frequency | Count | Frequency | p‐value | Count | Frequency | Count | Frequency | p‐value | |
| B5 | 13 | 4.06% | 2 | 4.76% | 0.689 | 3 | 2.50% | 12 | 4.96% | 0.402 | 13 | 4.33% | 0 | 0% | 1.000 |
| B7 | 8 | 2.50% | 0 | 0% | 0.604 | 4 | 3.33% | 4 | 1.65% | 0.448 | 8 | 2.67% | 0 | 0% | 1.000 |
| B8 | 1 | 0.31% | 0 | 0% | 1.000 | 0 | 0% | 1 | 0.41% | 1.000 | 1 | 0.33% | 0 | 0% | 1.000 |
| B12 | 0 | 0% | 1 | 2.38% | 0.116 | 0 | 0% | 1 | 0.41% | 1.000 | 0 | 0% | 0 | 0% | 1.000 |
| B13 | 33 | 10.31% | 4 | 9.52% | 1.000 | 13 | 10.83% | 24 | 9.92% | 0.854 | 31 | 10.33% | 2 | 10% | 1.000 |
| B15 | 62 | 19.38% | 6 | 14.29% | 0.531 | 19 | 15.83% | 49 | 20.25% | 0.391 | 58 | 19.33% | 4 | 20% | 1.000 |
| B16 | 22 | 6.88% | 0 | 0% | 0.091 | 10 | 8.33% | 12 | 4.96% | 0.244 | 22 | 7.33% | 0 | 0% | 0.379 |
| B17 | 25 | 7.81% | 5 | 11.90% | 0.370 | 9 | 7.50% | 21 | 8.68% | 0.840 | 24 | 8% | 1 | 5% | 1.000 |
| B22 | 35 | 10.94% | 4 | 9.52% | 1.000 | 16 | 13.33% | 23 | 9.50% | 0.283 | 32 | 10.67% | 3 | 15% | 0.469 |
| B27 | 2 | 0.63% | 2 | 4.76% | 0.068 | 1 | 0.83% | 3 | 1.24% | 1.000 | 2 | 0.67% | 0 | 0% | 1.000 |
| B35 | 11 | 3.44% | 1 | 2.38% | 1.000 | 4 | 3.33% | 8 | 3.31% | 1.000 | 11 | 3.67% | 0 | 0% | 1.000 |
| B40 | 58 | 18.13% | 9 | 21.43% | 0.672 | 22 | 18.33% | 45 | 18.60% | 1.000 | 52 | 17.33% | 6 | 30% | 0.224 |
| B46 | 44 | 13.75% | 7 | 16.67% | 0.637 | 16 | 13.33% | 35 | 14.46% | 0.873 | 41 | 13.67% | 3 | 15% | 0.745 |
| B48 | 5 | 1.56% | 1 | 2.38% | 0.526 | 3 | 2.50% | 3 | 1.24% | 0.403 | 4 | 1.33% | 1 | 5% | 0.277 |
| B67 | 1 | 0.31% | 0 | 0% | 1.000 | 0 | 0% | 1 | 0.41% | 1.000 | 1 | 0.33% | 0 | 0% | 1.000 |
Abbreviation: n, number of subjects.
a
Disease severity was classified as mild/moderate (mild symptoms up to mild pneumonia), severe (dyspnea, hypoxia, or >50% lung involvement on imaging) or critical (respiratory failure, shock, or multi‐organ system dysfunction) according to the WHO guidelines.