Table 2.

Synthesis of results: surfactant therapy in children

Boxes were colored in green or red if, for a given outcome, the surfactant treatment had a positive effect or not, respectively. Boxes were left blank where no data were available. No studies reported any biochemical or biophysical parameter

^†Trend which does not reach significance threshold

°A further article is not considered, since it was a post hoc analysis of a subgroup enrolled in one of these trials [44]

^*This trial investigated the administration of surfactant following recruitment maneuver versus standard care

Abbreviations: MOFS: multi-organ failure syndrome; PICU: pediatric intensive care unit