Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 26;73(1):23–40. doi: 10.1002/hep.31231

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Authors. Hepatology published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

PMC Copyright notice

Fig. 3 — HBV‐TERT‐promoter integration resulted in TERT activation and with poor clinical outcome. (A) TERT mRNA expression was significantly up‐regulated in HCCs with HBV integration at TERT locus, as compared with those without HBV integration. (B) Clinicopathologic correlation of TERT HBV integrations in human HCCs. Tumors having TERT HBV integration were associated with more frequent venous invasion and had a trend of association with more advanced tumor stage and poorer overall survival. (C) Clinicopathologic correlation of TERT promoter mutations in human HCCs. (D) Clinicopathologic correlation of collective TERT genomic alterations in human HCCs. *P < 0.05; **P < 0.01; ***P < 0.001. HPRT, hypoxanthine‐guanine phosphoribosyltransferase; NS, not significant.