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. 2021 Feb 1;1(2):e32. doi: 10.1002/cpz1.32

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© 2021 The Authors.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Senescence‐associated secretory phenotype (SASP) proteomic analysis figures generated by the Spectronaut software. (A) Heatmap depicting the abundance of all proteins identified in the conditioned medium of oncogenic RAS‐induced senescent (n = 6) and control (n = 6) IMR‐90 cells. (B) Volcano plot of the log 2 fold changes in abundance of proteins secreted by senescent versus control cells. Red dots represent fold changes >1.5‐fold, and p‐values >.05. (C) Line plot showing the abundance of a classical SASP protein, MMP1, in the secretomes of senescent and non‐senescent cells.