Table 2.
Genome map position and strength of the association for most significant SNP in each of the 39 phenotypes
| Phenotype | SNP | Chr | Bp | Candidate gene | Distance to gene (Bp) | Effect | P value |
|---|---|---|---|---|---|---|---|
| Anaerovibrio | rs320095924 | 8 | 3,650,253 | SORCS2 | 0 | − 0.364 | 8.89E−09 |
| Blautia | rs331690240 | 23 | 14,234,646 | ENSSSCG00000050465 | 0 | 0.475 | 2.14E−21 |
| Bulleidia | rs340048252 | 11 | 69,840,940 | NALCN | 0 | 1.086 | 5.29E−17 |
| Butyricicoccus | rs81361511 | 2 | 96,004,482 | ENSSSCG00000041042 | 71,388 | − 0.882 | 2.43E−15 |
| Campylobacter | rs81472036 | 18 | 15,768,346 | EXOC4 | 0 | − 0.708 | 6.09E−07 |
| Catenibacterium | rs81323962 | 3 | 74,840,151 | ETAA1 | 103,387 | − 0.567 | 8.52E−08 |
| Clostridium | rs81251808 | 4 | 60,750,431 | HNF4G | 113,341 | − 0.325 | 3.72E−09 |
| Collinsella | rs81430153 | 11 | 18,229,756 | PHF11 | 0 | 0.771 | 4.32E−07 |
| Coprococcus | rs81344777 | 3 | 4,420,359 | RBAK | 2425 | − 0.223 | 1.26E−07 |
| Desulfovibrio | rs331690240 | 23 | 14,234,646 | ENSSSCG00000050465 | 0 | 1.052 | 3.81E−14 |
| Dorea | rs81248474 | 6 | 8,320,740 | ENSSSCG00000042592 | 0 | − 0.199 | 1.34E−09 |
| Faecalibacterium | rs81288412 | 13 | 121,545,470 | ENSSSCG00000050978 | 3524 | 0.237 | 1.07E−17 |
| Fibrobacter | rs343652685 | 1 | 174,156,779 | ENSSSCG00000047027 | 156,250 | 1.092 | 3.99E−09 |
| Gemmiger | rs80980706 | 17 | 58,651,427 | VAPB | 6509 | 0.269 | 1.37E−08 |
| Lachnospira | rs329723588 | 15 | 137,647,629 | SCLY | 0 | − 0.545 | 1.84E−08 |
| Lactobacillus | rs81235044 | 4 | 121,603,127 | ENSSSCG00000046641 | 100,786 | − 0.743 | 2.77E−09 |
| Megasphaera | rs81371842 | 3 | 65,644,946 | ENSSSCG00000042171 | 273,629 | − 1.085 | 1.23E−08 |
| Mitsuokella | rs81358080 | 2 | 41,479,089 | ENSSSCG00000047282 | 5730 | − 1.094 | 3.68E−08 |
| Oscillospira | rs81344398 | 6 | 34,452,081 | ENSSSCG00000042964 | 722 | − 0.223 | 4.09E−10 |
| Parabacteroides | rs81242782 | 5 | 71,843,440 | LRRK2 | 0 | − 0.763 | 2.83E−06 |
| Peptococcus | rs81253718 | 2 | 43,124,329 | ENSSSCG00000045584 | 48,027 | − 0.907 | 1.44E−09 |
| Phascolarctobacterium | rs344728746 | 15 | 6,453,282 | ENSSSCG00000042287 | 110,243 | − 0.289 | 2.32E−09 |
| Prevotella | rs329143797 | 8 | 75,777,330 | TRIM2 | 0 | 0.178 | 1.56E−06 |
| RFN20 | rs81345563 | 2 | 44,851,717 | ENSSSCG00000033786 | 38,407 | − 0.571 | 7.63E−12 |
| Roseburia | rs81222575 | 8 | 19,050,584 | ENSSSCG00000041382 | 5304 | − 0.375 | 1.11E−08 |
| Ruminococcus | rs339681838 | 14 | 35,548,936 | FBXW8 | 0 | 0.133 | 1.26E−07 |
| Sphaerochaeta | rs81222575 | 8 | 19,050,584 | ENSSSCG00000041382 | 5304 | 0.776 | 3.58E−08 |
| Streptococcus | rs80787622 | 11 | 24,468,975 | TNFSF11 | 0 | 1.503 | 2.43E−12 |
| Succinivibrio | rs345030123 | 6 | 267,415 | FANCA | 0 | 0.967 | 3.82E−09 |
| Sutterella | rs322099448 | 8 | 74,295,221 | RBM46 | 16,663 | 0.826 | 4.34E−12 |
| Treponema | rs340048252 | 11 | 69,840,940 | NALCN | 0 | − 0.850 | 2.80E−10 |
| AlphaBACT | rs331027938 | 7 | 118,897,310 | ENSSSCG00000044157 | 12,891 | 0.141 | 1.10E−07 |
| Entamoeba | rs81323991 | 12 | 12,377,085 | ENSSSCG00000043117 | 7568 | 1.175 | 1.71E−08 |
| Hypotrichomonas | rs334181413 | 18 | 4,567,215 | ENSSSCG00000016426 | 0 | − 1.404 | 9.73E−09 |
| Trichomitus | rs81382396 | 4 | 10,874,687 | ENSSSCG00000047619 | 0 | 1.257 | 5.98E−07 |
| Tetratrichomonas | rs81280147 | 9 | 99,713,062 | CD36 | 0 | − 0.960 | 1.57E−08 |
| Neobalantidium | rs81323206 | 6 | 81,951,114 | IFNLR1 | 37,030 | − 1.948 | 7.05E−09 |
| Blastocystis | rs320737267 | 17 | 46,864,439 | TTPAL | 10,153 | 1.030 | 2.81E−12 |
| AlphaPROTO | rs80782515 | 17 | 28,489,220 | RALGAPA2 | 0 | 0.373 | 9.83E−11 |